2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-176754
    TCL065 1872269-57-2
    TCL065 is an ionizable lipid with a pKa of 6.3. TCL065 can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA as well as single-guide RNA (sgRNA) both in vitro and in vivo. TCL065-containing LNPs can studied in research for Duchenne muscular dystrophy and gene-editing technologies.
    TCL065
  • HY-176770
    GLP-1R agonist 34 3074089-99-6 98%
    GLP-1R agonist 34 (Compound 1) is an orally active small molecule glucagon-like peptide-1 receptor (GLP-1R) agonist. GLP-1R agonist 34 promotes insulin secretion, inhibits glucagon release, and delays gastric emptying, thereby effectively lowering blood glucose levels. GLP-1R agonist 34 is promising for research of metabolic diseases, including type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH).
    GLP-1R agonist 34
  • HY-176817
    GPR109 receptor agonist-3 944559-31-3
    GPR109 receptor agonist-3 is an orally active GPR109 receptor agonist, with an IC50 of 310 nM. GPR109 receptor agonist-3 retains the antioxidation and cytoprotection of Lipoic acid (HY-18733). GPR109 receptor agonist-3 reduces total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and increases high-density lipoprotein cholesterol (HDL-C) in high-fat diet-fed rats. GPR109 receptor agonist-3 can be used for the study of atherosclerosis.
    GPR109 receptor agonist-3
  • HY-176829
    FAHFA 18:1(9Z)/32-O-32:1(25Z) 98%
    FAHFA 18:1(9Z)/32-O-32:1(25Z) (OAHFA 18:1(n-9, cis)/ω-O-32:1(n-7, cis)) is an (O-acyl)-ω-hydroxy fatty acid (OAHFA) containing Oleic acid (HY-N1446) and 25(Z)-dotriacontenoic acid.
    FAHFA 18:1(9Z)/32-O-32:1(25Z)
  • HY-176855
    RAM1147
    RAM1147 is a farnesyl pyrophosphate synthase (FPPS) inhibitor. RAM1147 disrupts protein isoprenylation, inhibiting tumor cell proliferation. RAM1147 is promising for research of cancers (e.g., myeloma, breast cancer) and bone metabolism disorders (e.g., osteoporosis).
    RAM1147
  • HY-176873
    SLC6A19-IN-2 3102931-05-2 98%
    SLC6A19-IN-2 (Example 4) is a potent SLC6A19 inhibitor with an IC50 of 14 nM. SLC6A19-IN-2 can be used for the study of metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD) and phenylketonuria (PKU).
    SLC6A19-IN-2
  • HY-176929
    BET-IN-29 1776060-36-6
    BET-IN-29 (Compound 1) is a bromodomain and the terminal motif (BET) inhibitor. BET-IN-29 can be used for the study of cancer, inflammation, metabolism, neurological diseases, and infectious diseases.
    BET-IN-29
  • HY-176943
    PTH1R agonist 1 3106336-35-7 98%
    PTH1R agonist 1 (Example 2) is a parathyroid hormone 1 receptor (PTH1R) agonist. PTH1R agonist 1 can be used for research of hypoparathyroidism and osteoporosis.
    PTH1R agonist 1
  • HY-176944
    PTH1R agonist 2 3106850-44-3 98%
    PTH1R agonist 2 (example 3) is a parathyroid hormone 1 receptor (PTH1R) agonist. PTH1R agonist 2 can be used for research of hypoparathyroidism and osteoporosis.
    PTH1R agonist 2
  • HY-176945
    PTH1R agonist 3
    PTH1R agonist 3 (Example 47) is a parathyroid hormone 1 receptor (PTH1R) agonist with a pEC50 value of less than 6. PTH1R agonist 3 can be used for the study of bone diseases, such as osteoporosis.
    PTH1R agonist 3
  • HY-176961
    Homocholic acid 7170-94-7
    Homocholic acid is a synthetic steroid analogue. Homocholic acid can be labeled with 75Se and is used for SeHCAT detection (a method for diagnosing bile acid malabsorption).
    Homocholic acid
  • HY-176973
    DRP1 Allosteric-IN-1 1359386-11-0
    DRP1 Allosteric-IN-1 (Compound 1) is an allosteric inhibitor of DRP1 with an IC50 value for the DRP1:MiD49 protein-protein interaction of 3.6 μM. DRP1 Allosteric-IN-1 can be used to study various diseases related to mitochondrial division disorders.
    DRP1 Allosteric-IN-1
  • HY-176974
    DRP1 Allosteric-IN-2 3056559-91-9
    DRP1 Allosteric-IN-2 (Compound 2a) is an allosteric inhibitor of DRP1. Its IC50 value for the DRP1:MiD49 protein-protein interaction is 4.3 μM. DRP1 Allosteric-IN-2 can be used to study various diseases related to mitochondrial division disorders.
    DRP1 Allosteric-IN-2
  • HY-176975
    DRP1 Allosteric-IN-3 3056559-92-0
    DRP1 Allosteric-IN-3 (Compound 2b) is an allosteric inhibitor of DRP1. Its IC50 value for the DRP1:MiD49 protein-protein interaction is 11 μM. DRP1 Allosteric-IN-3 can be used to study various diseases related to mitochondrial division disorders.
    DRP1 Allosteric-IN-3
  • HY-176981
    TG (18:2_20:3_20:4) 98%
    TG (18:2_20:3_20:4) is a monoarachidonic triglyceride, belonging to the triacylglycerol lipid class.
    TG (18:2_20:3_20:4)
  • HY-176982
    TG (16:0_16:1_20:4) 98%
    TG (16:0_16:1_20:4) is a monoarachidic acid triglyceride, belonging to the triacylglycerol lipid class.
    TG (16:0_16:1_20:4)
  • HY-176983
    TG (16:0_18:2_20:4) 355807-60-2
    TG (16:0_18:2_20:4) is a monoarachidonic triglyceride, belonging to the triacylglycerol lipid class.
    TG (16:0_18:2_20:4)
  • HY-176984
    TG (18:0_18:2_20:4) 355807-62-4
    TG (18:0_18:2_20:4) is a monoarachidonic triglyceride, belonging to the triacylglycerol lipid class.
    TG (18:0_18:2_20:4)
  • HY-176985
    TG (18:1_20:2_20:4)
    TG (18:1_20:2_20:4) is a monoarachidonic triglyceride, belonging to the triacylglycerol lipid class.
    TG (18:1_20:2_20:4)
  • HY-176986
    TG (16:0_18:1_20:4) 98%
    TG (16:0_18:1_20:4) is a monoarachidic acid triglyceride, belonging to the triacylglycerol lipid class.
    TG (16:0_18:1_20:4)
Cat. No. Product Name / Synonyms Application Reactivity